BuyseTest: Generalized Pairwise Comparisons

Implementation of the Generalized Pairwise Comparisons (GPC) as defined in Buyse (2010) <doi:10.1002/sim.3923> for complete observations, and extended in Peron (2018) <doi:10.1177/0962280216658320> to deal with right-censoring. GPC compare two groups of observations (intervention vs. control group) regarding several prioritized endpoints to estimate the probability that a random observation drawn from one group performs better than a random observation drawn from the other group (Mann-Whitney parameter). The net benefit and win ratio statistics, i.e. the difference and ratio between the probabilities relative to the intervention and control groups, can then also be estimated. Confidence intervals and p-values are obtained based on asymptotic results (Ozenne 2021 <doi:10.1177/09622802211037067>), non-parametric bootstrap, or permutations. The software enables the use of thresholds of minimal importance difference, stratification, non-prioritized endpoints (O Brien test), and can handle right-censoring and competing-risks.

Version: 3.0.4
Depends: R (≥ 2.10), Rcpp
Imports: data.table, doSNOW, foreach, ggplot2, methods, lava, parallel, prodlim, riskRegression, rlang, scales, stats, stats4, utils
LinkingTo: Rcpp, RcppArmadillo
Suggests: cvAUC, mvtnorm, pbapply, pROC, R.rsp, survival, testthat
Published: 2024-07-01
DOI: 10.32614/CRAN.package.BuyseTest
Author: Brice Ozenne ORCID iD [aut, cre], Julien Peron [ctb], Eva Cantagallo [aut], William Anderson [ctb], Johan Verbeeck [aut]
Maintainer: Brice Ozenne < at>
License: GPL-3
NeedsCompilation: yes
Citation: BuyseTest citation info
Materials: NEWS
In views: CausalInference
CRAN checks: BuyseTest results


Reference manual: BuyseTest.pdf
Vignettes: BuyseTest: overview
BuyseTest: wilcoxon test


Package source: BuyseTest_3.0.4.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): BuyseTest_3.0.4.tgz, r-oldrel (arm64): BuyseTest_3.0.4.tgz, r-release (x86_64): BuyseTest_3.0.4.tgz, r-oldrel (x86_64): BuyseTest_3.0.4.tgz
Old sources: BuyseTest archive


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